Sentence examples for bind with high selectivity from inspiring English sources

An understanding of the mechanism by which minor groove binding agents interact with DNA has led to the design of agents that can reversibly bind with high selectivity to extended DNA target sequences.

PiB was designed to cross the blood-brain barrier, bind with high selectivity and nanomolar affinity to fibrillar Aβ, and clear rapidly from the brain [ 21].

The ability of antibodies to bind, with high selectivity and affinity, to diverse chemical structures has made them an extremely important tool for biomedical research [ 1].

The C-type lectin LSECtin, which is predominantly expressed on the liver and lymph node sinusoidal endothelial cells, has been demonstrated to bind with high selectivity to N-glycans displaying terminal GlcNAcβ1-2Man structures.

It binds with high selectivity to the extracellular domain of IGF-1R (and not to IR), leading to displacement of IGF-1 binding and loss of protein at the cell surface due to receptor internalization and degradation.

This molecular imaging protocol is based upon the protein annexin A5 (Anx A5), which binds with high selectivity and with great affinity (Ka = 7 n M) [ 27, 28] to the PS abnormally expressed on the cell membrane of apoptotic cells [ 21, 22, 29].

Also, in contrast to Trks which bind neurotrophins with high selectivity, p75NTR binds indiscriminately to neurotrophins, so future work may reveal whether p75NTR binds to Spzs.

We uncover that salts modulate protein dynamics and anions bind proteins with high selectivity and affinity, which is surprisingly masked by pre-existing ions.

(A ) Chemical structures of probe 1 and probe C. (B ) Schematic diagram illustrating the CLASPI strategy to profile proteins that bind H3K4Cr with high selectivity and affinity in whole-cell proteomes.

To identify proteins that bind H3K4Cr with high selectivity and high affinity, we performed two types of CLASPI experiments with cell lysates derived from HeLa S3 cells grown in medium containing either 'heavy' (C, N-substitued arginine and lysine) or 'light' (natural isotope abundance forms) amino acids.

The PH domain of Btk can also bind PIP3 with high selectivity, but in contrast to Akt, it is possible to activate Btk under conditions where PI3K activity has been blocked (Matsuda et al. 2009; Scharenberg and Kinet 1998; Suzuki et al. 2003b).