We found that the c-Myb DNA-binding domain can bind with high affinity to NrasI and NrasII, but with a reduced affinity to NrasIII.
Thiocyanate was discovered to bind with high affinity in the third anion-binding site at the bottom of the barrel.
Recombinant KatA was generated and shown to bind with high affinity to a region between heparin-binding domain 2 and 3 of Vn that differs from previously characterised bacterial binding sites on the molecule.
The hyaldherin molecules include structural matrix hyaluronic acid-binding proteins as well as cell surface receptors that bind with high affinity to hyaluronic acid [ 74].
Aminocyclohexyl indoles bind with high affinity and specificity toward the serotonin transporter (SERT).
All compounds from this series tested to date are antagonists which bind with high affinity.
Indeed, dextro enantiomers bind with high affinity σ1 receptor while opposite enantiomers bind opioid receptors.
The three peptides bind with high affinity to lipopolysaccharide as demonstrated by monolayer penetration and dansyl-displacement.
Bile acids bind with high affinity to selective pockets in this cavity, enhancing dimer assembly and enabling catalysis.
In vivo, the extracellular region of TrkB is known to bind, with high affinity, the neurotrophin protein brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4).
AT utilises an induced-fit mechanism to bind with high affinity to a pentasaccharide sequence found in about one-third of heparin chains.
