Suggestions(2)
Exact(1)
The large number of additional, lateral binding sites sometimes creates large cooperativity effects that enable filaments to bind with extreme affinity to their partner, even if the individual binding energies, per subunit, are rather small.
Similar(59)
1A and B bind with approximately equal affinity, although the exact affinity could not be obtained as each DNA binds more than one MA.
These analogues bind with extraordinary affinity relative to reactants.
Indeed, dextro enantiomers bind with high affinity σ1 receptor while opposite enantiomers bind opioid receptors.
First, they bind with high affinity and specificity to a wide variety of proteins.
It could be so that antibodies, to be protective, need to bind with high affinity.
All three bind with high affinity to the Nogo-66 receptor (NgR) on axonal surfaces [1] [3].
Thus, in this in vitro system, both peptides bind with medium affinity (µM range) to HSC70.
Many ER resident proteins are prevented from being secreted via an ER retention motif (KDEL) at their extreme C-terminus, which binds with high affinity to KDEL receptors (KDEL-R) located in the intermediate compartment or in the cis-Golgi (37).
Conversely, clonazepam binds with high affinity to CBR, but has extremely low affinity for PBR (Wang et al, 1984b).
Importantly, ADP binds with low affinity, which is insufficient to interfere with binding or release of these high affinity inhibitors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com