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These analogues bind with extraordinary affinity relative to reactants.
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1A and B bind with approximately equal affinity, although the exact affinity could not be obtained as each DNA binds more than one MA.
This indicates that Mg2+ and Ca2+ bind with similar affinity to open and closed states of the channel.
Indeed, dextro enantiomers bind with high affinity σ1 receptor while opposite enantiomers bind opioid receptors.
We also now reveal that its epitope is largely conserved: mAb 85RF45.1 can accommodate all sequence polymorphisms previously reported and still bind with nanomolar affinity.
Furthermore, NK1 antagonists bind with similar affinity to gerbil, guinea pig, and human NK1 receptors (Beresford et al. 1991; Gitter et al. 1991).
A key requirement for a small molecule drug to exert a pharmacological effect is to bind with sufficient affinity and duration to its target protein.
First, they bind with high affinity and specificity to a wide variety of proteins.
All Envs bound to CD4 binding site, membrane-proximal, and V1/V2 MAbs with similar apparent affinities, although the T/F Envs bound with higher affinity to the MAb 17b, a CCR5 coreceptor binding site antibody.
K5 binds with high affinity (Kd of 28 nm) to endothelial cells, and binding is inhibited by these antibodies.
ING2, a native subunit of a repressive mSin3a-HDAC1 histone deacetylase complex, binds with high affinity to the trimethylated species.
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