Sentence examples for bind with enhanced affinity from inspiring English sources

This used a bivalent hapten that could cross-link bispecific antibody molecules at the surface of target cells and bind with enhanced affinity (or avidity), whereas, in the circulation, binding remained rapidly reversible, avoiding the need for a chaseof excess bispecific antibody.

As shown by EMSA, the engineered variants bind DNA with enhanced affinity (16-fold) in the absence of the α2 cofactor and the variant α2/a1 heterodimers bind cognate DNA with specificity and affinity reflective of the enhanced a1 binding affinity.

This novel compound inhibits Shaw2 K+ channel currents similarly to isoflurane and binds to apoferritin with enhanced affinity.

As a pair, the two PAM2 sites bind to MLLE together with enhanced affinity and are responsible for essentially all of the free energy of binding between the intact proteins, eRF3 and PABPC1 [24].

60 It binds VEGF-A receptors with enhanced affinity and inhibits vasculogenesis.

This protein is recruited from the cytosol onto the surface of late endosomes by Rab9 GTPase, which enables TIP47 to bind to MPR cytoplasmic domains with enhanced affinity.

Measurements of the fluorescence anisotropy change on DNA binding indicated that apaMyoD bound to E-box-containing DNA sequences with enhanced affinity relative to MyoD-bHLH.

Moreover, EBs bind with widely varying affinities to microtubules grown in the presence of different GTP analogs notably with enhanced affinity for GTPγS microtubules compared to GDP microtubules (Maurer et al., 2011)—suggesting that EBs might instead sense a tubulin conformation that is linked to tubulin's GTPase cycle at growing microtubule ends.

Several old drugs that bind to SARS 3CLpro active site were selected and in silico derivatized to generate covalent irreversible inhibitors with enhanced affinity.

As a key functional component of this tandem Fcɛ Fcγ biologic, we engineered its IgG1 Fc domain to bind to human FcγRIIb with 100-fold enhanced affinity relative to native IgG1 Fc.

We found that the c-Myb DNA-binding domain can bind with high affinity to NrasI and NrasII, but with a reduced affinity to NrasIII.