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The most often seen interaction is to Asp235, and most compounds bind with a specific orientation that is defined by their ability to interact with this residue.
Peptide growth factors play a role in the rebuilding of extracellular matrix in the course of leiomyoma growth, and exert a regulative effect on the cell only when they bind with a specific membrane receptor and transmit a signal into the cell.
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A drug (D) binds with a specific three-dimensional receptor (R) in the body forming a drug receptor complex (DR).
Known as the "olfactory epithelium," this tissue is shot through with thousands of receptors, each made of a protein that will bind only with a specific chemical.
Here we describe a strategy which enables the identification of antibodies that bind unknown receptors with a specific expression profile.
A novel and efficient tagArray technology was developed that allows rapid identification of antibodies which bind to receptors with a specific expression profile, in the absence of biological information.
Aptamers are single-stranded DNA or RNA molecules that can selectively bind to a specific ligand with high affinity and specificity.
In novel drug design, compounds are usually engineered to bind to a specific target, with the assumption that one drug binds to one target to treat one condition.
Consistent with these findings, anti-GRP78 autoantibodies that were isolated from the serum of patients with prostate cancer and bind to a specific N-terminal epitope (Leu 98 -Leu(115)) on ceLeu 98 -LeuGRP78, caused a dose-dependent increase in cytosolic [Ca(2+)] and enhanced TF PCA.
A recent alternative approach is a vibrating quartz crystal coated with antibodies that bind a specific virus.
In the first pathway, TnsABC (the core recombinase) interacts with TnsD bound to a specific site, attTn7, to promote integration adjacent to the glmS gene providing a safe-haven for the transposon [24].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com