Sentence examples for bind with a high from inspiring English sources

This finding suggests that the IgM isotype introduces the potential of multivalent binding, allowing oligomers to bind with a high affinity, while monomers and dimers bind only transiently with fast off-rate kinetics.

Hsp90 inhibitors bind with a high affinity to the ATP-binding pocket and block the chaperone ATPase cycle leading to the degradation of client proteins (2, 3).

Compared to single-target drugs that bind with a high affinity to their target, multi-target drugs are considered low-affinity binders [6].

Hence, there exist mainly three scenarios for the design of a multi-target drug: a) Two ligands that bind with a high affinity to distinct targets are used to "design in" a new ligand by uniting their structural elements responsible for activity.

It was suggested that EGCG can bind with a high affinity to the catalytic site of human COMT.

They can bind with a high affinity and specificity to a target molecule through complementary shape interactions as a result of their three-dimensional shape.

Previous research evaluating the direct binding of LILRs to HLAIs [20] demonstrates that Group 1 LILRs bind with a higher affinity to non-classical than classical HLAIs.

Consistent with previous observations for Src and Hck, αC helix-out ligands 6 and 7 bind with a higher affinity to SFKSH2eng constructs than to activated SFKs.

The binding studies show that the CTD of primase binds with a high affinity to the full length helicase and NTDL; poorly with NTD of HpDnaB alone.

LMO4 binds with a high affinity to the LIM domain-binding proteins, LDB1 (CLIM2, NLI1) and LDB2 (CLIM1) (Agulnick et al, 1996; Jurata et al, 1996; Sugihara et al, 1998).

A joint starting point of many drug design approaches is an exhausting search for a drug-like molecule that binds with a high affinity to a desired biological target.