The C subunit of Hdr contains two [4Fe-4S] cluster-binding EFLs with the same signature, as in subunit A. HdrB is the catalytic domain, which uses another [4Fe-4S] cluster (bound with a different cysteine-rich signature) and also contains several redox-active cysteine residues.
However, because we cannot exclude that different substrates might bind with different kinetics to potentially different proteasome isoforms we prefer to infer X enh separately for the three substrates.
It was recently reported that Oct4 may preferentially bind to a different motif with consensus ATGCGCAT when not binding near Sox2 Masonn et al., 2010).
Estrogens bind with different affinities to these different ER types [ 46, 47], which could provide diverse physiological outcomes in unique circumstances or stages of development.
Explicitly, an SNP can lead to (1) a loss of the binding site, (2) a change of binding site, meaning that due to the SNP a different TF binds the region or that the same TFs can bind to the site but with a different affinity, (3) a creation of a new binding site in a region where previously no binding site was known, or (4) no change at all.
The UBAN motif is known also to recognize ubiquitin chains with other linkages - in particular K63 chains, which are also present on components of the TNF-RSC, including on RIP1 [ 19]; but the UBAN of NEMO binds linear di-ubiquitin with a different topology and about 100-fold higher affinity than it does K63-linked di-ubiquitin.
Met31 has an asymmetric binding site, so it can possibly bind with two different orientations.
The name wd is bound to a function with a balance of 20, while wd2 is bound to a different function with a balance of 7. Calling wd2 changes the binding of its non-local balance name, but does not affect the function bound to the name withdraw.
Even though all type I IFNs use the same receptor it has been shown that they bind with different affinities and even induce different sets of interferon-stimulated genes (Lavoie et al., 2011).
Neoplastic cells, morphologically normal prostate epithelium cells and BPH epithelia bind testosterone-BSA analog but with a different intensity.
