An IDR (intrinsically disordered region) within an IDP often undergoes disorder-to-order transitions upon binding to various partners, allowing an IDP to recognize and bind different partners at various binding interfaces [ 8, 51, 52].
Integrin β1 can bind to various ECM components depending on its α subunit partner: the heterodimers α2 β1, α3 β1 and α5 β1 bind preferentially to collagen, laminin and fibronectin, respectively.
Since HFRs can provide sites for a multitude of target proteins and GAF can bind to various proteins to form regulatory complexes, looking for interacting partners at these sites will help identify other regulatory features at the HFRs.
The prion protein (PrP) binds to various molecular partners, but little is known about their potential impact on the pathogenesis of prion diseases Here, we show that PrP can interact in vitro with acetylcholinesterase (AChE), a key protein of the cholinergic system in neural and non-neural tissues.
Proteoliposomes were allowed to bind to various amounts of uPA immobilized on 50 μl of Sepharose 4B gel.
First, coupling to various partner proteins affects the substrate specificity of translocases and single translocation steps.
Much of academic research viewed civil conflicts as tightly bound to various grievances by internal factions within the state.
A promiscuous protein is defined as protein with a defined sequence that can bind various partners (but still exhibits high specificity for this particular group of partners) without utilizing different epitopes, making promiscuity an incomprehensible mystery in protein-protein recognition.
Our recent study of the complexes that form when various disordered segments bind to ordered partners indicates that the disorder-associated binding regions have distinct sequence features, even when the bound structure is irregular or sheet instead of helix, and so it should be feasible to develop a specific predictor for each of the different types of MoRFs [ 137].
We rather consider it as a strong indication that these proteins have gained, during evolution, the capability to bind to more partners when needed; another way to augment adaptability to various environments.
