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Interestingly, however, MIF does not bind to unrelated sequences that contain a perfectly conserved 8 bp MEE2 core motif.
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The siDirect software minimizes nonspecific complementarity of siRNA sequences to reduce binding to unrelated sequences.
Frank stated that 'Paratopes and epitopes define complementary regions of shape and charge rather than particular amino acid compositions'; and 'A single paratope can bind unrelated epitopes and a single epitope can bind to unrelated paratopes' (Frank 2002).
To demonstrate the specificity of these interactions, the ability of carboxy-terminal peptides from SynGAP1, TAPP1 and EphA7 to bind to unrelated PDZ domains was assessed.
Using serpins as a paradigm, we show how the active and infective interface of oligomers is inherently toxic and can promiscuously bind to unrelated peptides, including neurotransmitters.
Recombination events may lead to homologous sequences not being detected due to the insertion of unrelated sequences; or to unrelated sequences being erroneously identified as homologs when small stretches of evolutionary related sequences are inserted.
Thirdly, we compare the conformational variation in two sets of ligand molecules, those bound to homologous proteins, and those bound to unrelated proteins.
In addition, these scFvs did not bind to other unrelated peptides like MPER and ID loop of HIV, peptide pool (unrelated viruses) and BSA.
SH3 domains bind to proline rich sequences.
For example, a monoclonal antibody raised against the HIV-1p24 protein can bind to several unrelated peptides [ 55].
KLF17 has been known to bind to CACCC box sequences.
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