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VEGF-soluble proteins bind to two specific tyrosine-kinase receptors, VEGFR-1 (flt-1) and VEGFR-2 (flk-1/KDR), which are expressed preferentially in endothelial cells.
TNF- α can bind to two specific receptors: TNFR1, with an intracellular death domain, and TNFR2, with a higher affinity and mostly involved in neuroprotection [ 42].
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As to the infection of a permissive host cell, CVB3 mainly binds to two specific cell surface receptors, the coxsackievirus and adenovirus receptor (CAR) or the membrane protein decay accelerating factor (DAF).
For typical affinities and concentration values, the average number of Ste5 bound to one specific kinase is 19 while the average number of Ste5 simultaneously bound to two kinases is 0.19 (and 0.0019 for three kinases simultaneously bound).
Adiponectin binds at the cellular level to two specific transmembrane receptors, adiponectin receptor 1 (andpoR1) adiponectinctin receptor 2 (AdipoR2) [ 14, 15], which provokes an intracellular activation of the 5'-AMP-activated protein kinase (AMPK) and PPAR-alpha [ 16].
S1P binds mainly to five specific G-protein-coupled receptors (GPCRs), S1P1−5 [ 38].
Although the work cited above provides convincing evidence that the DOCK180/Mbc-ELMO complex is essential in development, the mechanism by which at least five Rac-specific DOCK proteins bind to one or more ELMO proteins in vertebrates to modulate actin regulation in a tissue-specific manner is not clear.
TRAIL can bind to four membrane receptors.
Serological tests have been made more specific and convenient to perform since the discovery of a technique to produce large quantities of monoclonal antibodies, which bind to only one specific antigen.
Researchers have long known that these proteins bind to DNA in a modular fashion, with each "finger" recognizing three to four specific nucleotides.
Select one to three specific locations.
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CEO of Professional Science Editing for Scientists @ prosciediting.com