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Given the short distance (6 bonds excluding side-arms of K-residues) between two RGD motifs in E[c RGDfK ]2 and E[c RGDyK ]2, it is unlikely that they would bind to two adjacent αvβ3 sites simultaneously.
Both Ikaros and Aiolos can bind to two adjacent Ik1 and Ik2 sites proximal to the λ5 transcription start site.
Similar(58)
The robust mechanism involves the RP cycle catalyzed primarily by RP bound to two adjacent subunits of PPDK, one in PPDK2 form and the other in PPDK2 form.
The surface atoms on the perfect polar faces are tightly bound to three adjacent atoms in the bulk material, while the atoms in the underlying layer are only bound to one atom in the bulk.
Binding of a single EPO molecule to two adjacent EPO receptors on the membrane of target cells leads to homodimerization of the receptors and the triggering of different intracellular signaling pathways that might play an as yet unidentified role in cellular protection from stress.
It might be that these domains are orientated such that they are able to simultaneously bind to both the phosphorylated serine and the phosphorylated threonine of a single SDTD motif, or to two adjacent SDTD motifs in the MDC1 protein.
It thus converts adjacent PPDK1- PPDK2 subunits either to two adjacent PPDK1 subunits, or two adjacent PPDK2 subunits.
As transcriptional activator, reduced OxyR binds to two pairs of adjacent major grooves separated by one helical turn of the DNA duplex and acts to repress its own synthesis.
The ratio of two types N indicates that they are mainly bonded to three adjacent carbons, suggesting that the N atoms are uniformly bound to the graphene structure.
In order to achieve bivalency, the distance between two cyclic RGD motifs must be long enough so that they will be able to bind the two adjacent αvβ3 sites simultaneously.
We reasoned that loss of Golgi ribbon structure may be related to KIF1C's ability to bind Rabs at both ends, which could in theory, be used to bind and link two adjacent membrane compartments.
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