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Besides death receptors, TRAIL can also bind to two additional plasma membrane-bound receptors, TRAIL-R3 and TRAIL-R4.
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Interestingly, Snail1 is unable to bind to four additional consensus boxes or to the three perfect-match E-boxes contained in 3 kb or between 7 and 8 Kb fragments upstream of the Runx2 coding region, respectively.
Structures of CS-35Fab bound to two additional tetrasaccharides confirm the general mode of binding seen in the hexasaccharide and indicate how different parts of LAM are recognized.
CtrA also binds to four additional sites downstream of the S6 TSS suggesting a complex mechanism of autoregulation.
In the case of PelN, three aspartates (Asp, Asp, and Asp) were predicted to bind to two Ca2+ ions [Additional file 1] by MSA analysis.
Rb has been shown to bind to four members of the E2F family of transcription factors (E2F1-4) and over 100 additional cellular proteins (Morris and Dyson, 2001).
TRAIL can bind to four membrane receptors.
We also observed an additional minor component at higher MW (m/ z 17148 Da), resembling PanZ bound to two equivalents of CoA – we hypothesise that this second species corresponds to PanZ bound to the covalent CoA disulphide.
18 Lithium atoms bound to two NHMDS atoms are distorted trigonal-planar, while those attached to two iodine atoms are distorted tetrahedral owing to additional coordination by bidentate (R, R -TMCDA ligands.
Corticosterone binds to two types of receptors.
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