This is further supported by our modeling studies, showing that NeoR6 and CXCL12 bind to two distinct sites on CXCR4, in contrast with other CXCR4 inhibitors, e.g. T140 and AMD3100.
Ang II possesses the capacity to bind to two distinct receptor subtypes, AT1 and AT2 [45].
The ET family consists of three isopeptides, ET-1, ET-2, and ET-3, which bind to two distinct subtypes, ETAR and ETBR, of G protein-coupled receptors [20].
Or, this percentage is within the range of cells expressing two TCR alpha chains that could bind to two distinct tetramers via two distinct TCRs.
To mediate its immunosuppressive function, CD73 generated adenosine can bind to four distinct G-protein-coupled receptors: A1, A2A, A2B, and A3.
The endothelin system consists of three peptide ligands (ET-1, ET-2, and ET-3), which bind to two distinct G protein-coupled receptors designated ETA and ETB [ 4].
The latter case is critical when drug is able to bind to two distinct membrane receptors, becoming a ternary system that additionally requires an average distance between receptors to be considered.
TFII-I was originally identified as a transcription factor that could bind to two distinct promoter elements: the pyrimidine-rich initiator and the recognition site (E-box) for upstream stimulatory factor 1 (USF1).
Notably, the benzimidazole scaffold is another known privileged structure, providing an explanation for why CF15 and CF18 bind to two distinct sites in PHD HD1 to its benzothiazole cleft and its K4me pocket.
Estrogen bind to two distinct estrogen receptors (ERa and ERβ), which are encoded by genes located on two different chromosomes, whereas progesterone binds to two isoforms of a receptor (PR-A and PR-B) that are transcribed from the same gene by different promoters [11], [12].
