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A general question is how motors search for sites in the cell where both motor ends can bind to their respective binding partners.
To investigate the effect of binding of the ions and the substrate on protein dynamics, one would ideally design and perform equilibrium MD simulations of the protein in the presence of these species initially placed in the bulk and monitor their movement over time as they diffuse, find, and bind to their respective binding sites.
These transcription factors bind to their respective putative binding sites and initiate the transcription of type I IFN, which activates auto- or paracrine pathways to initiate the antiviral responses.
Here, we present a structural comparison of the important and similar interactions necessary for Gleevec®, Nexavar®, and BIRB-796 to bind to their respective DFG-out allosteric binding pockets and the selectivity of each with respect to c-Abl, B-Raf, and p38α.
It appears that at least two molecules of glycine and GABA must bind to their respective receptors to activate a chloride channel.
Radioactively labeled DA, NE and 5-HT bind to their respective receptors and substances with affinities to the respective receptor displace the radiolabeled neurotransmitter.
Similar(21)
Following activation of naive TH1 cells, NFAT, NF-κB and STAT4 had to be bound to their respective binding sites in the promoter region of twist1 to induce its transcription, whereas in activated TH1 cells, NFAT and NF-κB binding to the twist1 promoter region was sufficient to trigger its expression.
In eukaryotes, the combination of TF binding sites clustered together near the transcription start sites in the promoter of genes are known as cis regulatory modules (CRMs), and changes in the combination of TFs bound to their respective binding sites contribute to up or down-regulate gene expression levels [ 4].
The crystal structures of TAL effector (TALE) proteins bound to their respective target DNAs have revealed that the residue at position 13 is the only one directly involved in DNA base recognition, whereas the 12th residue stabilizes the proper loop conformation (Deng et al., 2012a; Mak et al., 2012).
The crystal structure of the ternary molecular complex of RARα-atRA/RXRα-LG100754 LBDs and TIF-2 coactivator peptide was solved at 2.75 Å resolution and contains the two receptor LBDs bound to their respective ligands.
At this stage the peptide bound to their respective antibodies (anti-HIV-1 specific).
More suggestions(15)
bind to their common
bind to their adjacent
bind to their extracellular
bind to their heterodimeric
bind to their cognate
bind to their genomic
bind to their complementary
bind to their mRNA
bind to their nucleosomal
bind to their large
bind to their presynaptic
bind to their putative
bind to their regulatory
bind to their specific
relates to their respective
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com