Sentence examples for bind to their large from inspiring English sources

Intracellular protein protein interactions (PPIs) are challenging targets for conventional drug modalities, because small molecules generally do not bind to their large, flat binding sites with high affinity, whereas monoclonal antibodies cannot cross the cell membrane to reach the targets.

Peptide hormones such as AII share the property that they bind to their receptors with high affinities, in spite of the fact that they must overcome an extremely large conformational entropy barrier to bind in one conformation.

Two boys stand before the camera, each wearing rough eyemasks, their naked upper bodies smeared with something grim-looking, large horns bound to their heads and rope in their hands.

While Class I HLAs bind to shorter peptides around 9-mers, Class II HLAs can bind to a large variety of peptides around 15-mers or longer due to their open-ended binding grooves.

Three-dimensional protein motion in the cellular environment complicates measurements; however, many proteins bind to larger cellular structures, restricting their motion.

The substrates for these transporters bind to large external loops, which vary in size among the different transporters.

The results reveal that the new derivatives are less mobile and bind to a larger pocket in the channel.

Researchers already knew how to force tiny molecules to bind to larger ones to create a big foreign substance the immune system could not miss.

Larger proteins can enter the mitochondrion if a signaling sequence at their N-terminus binds to a large multisubunit protein called translocase of the outer membrane, which then actively moves them across the membrane.

Scientists use small bits of DNA called expressed sequence tags, or ESTs, to bind to larger DNA fragments and find new genes.

For example they might bind to larger carrier proteins or there might be some unknown mechanisms for them to be retained for an extended period in the plasma.