Sentence examples for bind to their extracellular from inspiring English sources

Our algorithm finds a 7-TM binding cavity also for class C receptors, even though their natural ligands bind to their extracellular N-terminal domains.

Although the natural ligands of class C receptors bind to their extracellular N-terminal domains, the possibility of modulating their activity through ligands that bind to their helical bundle has been reported.

Wnt receptors, Frizzleds, are seven-transmembrane proteins to which Wnts bind to their extracellular part, the cysteine-rich domain (CRD) [ 2].

These helical cytokines all bind to the extracellular binding domains of their cognate receptors (helical cytokines receptors: HCR) which all contain a 200 amino-acids (D200) domain that is the identification mark of the HCR gene family.

To define epitopes of functional relevance, 11 monoclonal antibodies (MAbs) were evaluated for their ability to bind to the extracellular domain of p185.

The FGFR ligands are secreted proteins that bind to the extracellular matrix, thereby restricting their influence to the tissue where they are produced (autocrine or paracrine function).

There are currently more than 40 peptide drugs approved for clinical use, the majority of which bind to the extracellular targets because of their inefficient cell permeability.

Cadherins bind with their extracellular domain to other Cadherins and with their intracellular domain to molecules linking them to the cytoskeleton [ 30].

Their mode of action is to bind to the extracellular domain of a target GF receptor, which in turn activates the intracellular signal transduction pathways.

Since trastuzumab must bind to the extracellular domain of HER2, a depressed HER2 surface pool hinders binding.

Divalent cations, such as Ca2+ and Mn2+, bind to the extracellular domain of ITGAs, and also induce the ITGA-mediated cell adhesion activity12.