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Identifying direct interactions between OsHsfC1b and cis-regulatory elements of stress-related target genes is of further interest, as OsHsfC1b has been reported not to bind to the typical HSE element (Mittal et al. 2011).
The RBR E3 enzyme Parc (also known as Cul9) also contains a Cul7-like domain that can bind to the typical CRL partners including Rbx1 (RING-box 1, E3 ubiquitin protein ligase) and NEDD8 [ 88, 89].
Although untypical but in accordance to our finding, that HuR did not bind to the typical AREs present in the 3′UTR of the three different caspase-2 splice variants, the steady-state level of caspase-2L mRNA were significantly elevated in HuR-siRNA-depleted cells when compared with control-siRNA transfectants.
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We find that temporal patterns of service usages are bound to the typical weekly cycles of humans, yet they show maximal activities at different times.
RPPs can thus overcome the antimicrobial effect of typical tetracyclines, which bind to the ribosome and inhibit the elongation phase of protein biosynthesis [ 107].
First, PBA is not a positively charged molecule, which is typical for hERG blockers that bind to the hydrophobic residues in the S6 helix [43].
In all five of these structural models, each CaS100B subunit consists of four helices (helix 1, E2 G19; helix 2, K28 L40; helix 3, E49 D61; helix 4, D69 F88), two small antiparallel β-strands, and a Ca2+ ion bound to both the typical and noncanonical EF-hand calcium binding domains.
In typical cells, the non-receptor tyrosine kinase FAK is activated by clustering of integrins as they bind to the extracellular matrix (Mitra and Schlaepfer, 2006).
A recent report of the crystal structure of a CcP guaiacol complex obtained by soaking the CcP crystals in a substrate solution showed that guaiacol does not bind at the typical heme-edge binding site of monofunctional peroxidases (reviewed in ref (11)).
Plakoglobin binds to the cytoplasmic cadherin-typical sequence of Dsgs and Dscs via its first three armadillo repeat domains (Chitaev et al. 1998).
Interestingly, the human Oct-4B isoform does not bind to DNA carrying the typical Oct-4 consensus-binding sequence, is mainly localised to the cytoplasm, and does not activate transcription from an Oct-4-dependent promoter (Lee et al, 2006).
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