Sentence examples for bind to the pore from inspiring English sources
Agonist molecules can bind to the pore and block ionic conduction.
EF and LF bind to the pore entrance to be translocated into cytosolic space.
EF and LF bind to the pore entrance and translocate to the cytosol with a cytosolic translocation factor chaperone [7].
The molecular basis of this process is becoming clear: store depletion leads to oligomerization of the ER protein STIM1, and the oligomers then migrate to ER-plasma membrane junctions, where they bind to the pore-forming subunit of the CRAC channel Orai1 and trigger the channel to open [ 10].
We have also shown that Bax binds to the pore of Kv1.3, subsequently resulting in the inhibition of Kv1.3 activity in isolated mitochondria.
These interactions poise LFn bound to the pore to undergo translocation from the N- to C-terminus by a charge state-dependent Brownian ratchet mechanism, driven primarily by the transmembrane proton gradient.
At symmetrical pH 5.5 and a low (δ20 mV) cis-positive potential, LFN binds to the pore and blocks ion conductance through it, an activity dependent upon the highly charged N-terminal segment of LFN.
This subunit binds to the pore-forming α1 subunit of the channel with a 1 1 stoichiometry; thus, expression of this protein in cardiomyocytes represents a photo-activatable fluorescent marker of CaV1.2 channels.
Some NCIs have a high affinity specifically for D AChRs, while others may also act as traditional channel blockers that bind to the open pore [10], [11], [12].
These drugs (e.g. astemizole, E-4031) specifically bind to the transmembrane pore of WT hERG and block channel function.
