Sentence examples for bind to the outward from inspiring English sources

The individual amphetamine-derived compounds differ in their affinity for specific transporters but their principal mechanism of action is identical: they bind to the outward facing conformation of the transporter and translocate together with Na+ and Cl− from the extracellular side into the cell interior (Rudnick and Wall, 1992; Sitte et al., 1998; Seidel et al., 2005).

(iii) Importantly, however, the addition of 10 μM paroxetine, which binds to the outward-open state of SERT, was shown to reveal no additional change in FRET relative to that with sodium alone.

If the single Cse4p nucleosome broadly lies along the microtubule's long axis, the KMN complexes would have to radiate from this central point outward to be able to bind to the external wall of the microtubule.

Indeed, in a different secondary transporter called LeuT, an OG detergent molecule binds to the extracellular cavity and stabilizes the outward-facing conformation (Nissen and coworkers).

Consequently, as long as the amphetamine is bound, the transporter would not undergo a transition to the outward facing conformation (TIK to TOK in our model).

Specifically, cyclosporine binds to the cyclophillin receptor.

The threshold model was used to relate a hypothetical underlying scale to the outward categorical response.

Cocaine binds to and stabilizes the outward- (extracellular-) facing conformation of the dopamine transporter (DAT) protein, while the low abuse potential DAT inhibitor benztropine prefers the inward- (cytoplasmic-) facing conformation.