Sentence examples for bind to the open from inspiring English sources
The tools for MHC class II binding exhibit declined performance, owing to the variable length of the peptides that bind to the open groove of the MHC class II molecule.
Some NCIs have a high affinity specifically for D AChRs, while others may also act as traditional channel blockers that bind to the open pore [10], [11], [12].
Some miRNAs can bind to the open reading frame or 5'UTR of target genes; moreover, they have been shown to activate, rather than to inhibit, gene expression [ 21, 24, 25].
MiRNAs bind to the 3′UTR of target mRNAs and either block the translation of the message or bind to the open reading frame and target the mRNA transcript for degradation.
Quantitative RT-PCR (qRT-PCR) was carried out in 25 μL of a reaction mixture containing 2.5 μL of cDNA, 12.5 μL of Supermix (BioRad), a 400 nmol/L concentration of each primer designed to bind to the open reading frame 1 and 2 junction (36 ), and 15 pmol of RING1(a -TaqMan probe a -TaqManl of RING1(b)-TaqMan probe fluorogenic probes for NV genogroup I (GI) detection.
All of the active compounds bind to the open-inactivated states of the channels and therefore act as state-dependent modulators.
The results suggest that the agent preferentially binds to the open state of the K+ channel [30], [31].
Mechanistic and structural studies indicate that erlotinib binds to the open, active conformation of HER1 kinase domain [ 58], while lapatinib binds to the closed, inactive conformation [ 55].
It seems likely that the β-turn segment is dynamic, fluctuating between open and closed forms; the substrate binds to the open form, perhaps by conformational selection.
By weakening interactions of the N-subdomain believed to stabilize the closed complex, an intermediate complex with an incoming nucleotide bound to the open conformation was determined.
Two ligands (ACD and AOB) are bound to the open form of FABP4, and the other two (ANS and TGZ) are bound with the closed form in the crystal structures.
