Sentence examples for bind to the mutant from inspiring English sources
We found that c-Jun binds to the AP-1 DNA binding site following JSI-124 treatment whereas c-Jun failed to bind to the mutant AP-1 site.
Several mutant ligands in the ensemble are expected to bind to the mutant receptors, and then the ensemble may create a defensive wall surrounding the target receptors in receptor-sequence space.
The aim of this work was to synthesize and evaluate radiolabeled compounds that bind to the mutant IDH1 enzyme with the goal of enabling noninvasive imaging of mutant IDH1 expression in gliomas by positron emission tomography (PET).
If they could find a molecule that would bind to the mutant CRYAB protein and lower its melting temperature back to that of a healthy CRYAB, they speculated, CRYAB should function normally and prevent damaged proteins from clumping in the lens.
In agreement with this, SPR measurements with the XcOGT-D471A mutant revealed that neither UDP nor C-UDP bind to the mutant enzyme (Table 2).
Allosteric control is engineered into an enzyme by structurally weakening the enzyme through mutation to the point that its enzymatic activity is abolished, then identifying a small molecule able to bind to the mutant protein and restore its original structure.
From Table 3, when TP5 bound to the mutant DR11, the binding energy had a slight change; however, Ala11 completely lost its role as a binding site.
Whereas, when TP5 bound to the mutant DR62, the binding energy had a distinct change; Ala62 remained to exert a positive role as a binding site, suggesting that Asn anchor mainly contributed to the binding energy.
The mutant retained specificity for ATP; ADP and GTP bound to the mutant with dissociation constants 16 and 53 μM, respectively.
Even in the reaction in which more αCTD bound to the mutant promoter than the wild-type promoter, Spx was unable to supershift the mutant promoter complex as efficiently as the wild-type promoter complex (Figure 8, lanes 11 to 16).
