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All NLSs bind to the major binding site, spanning armadillo repeats 1 4, and some also have a small additional contribution from the minor site, spanning repeats 6 8.[ 8] TPX2, however, binds primarily to the minor site of importin-α, thereby offering an opportunity for selectivity.
G4 PAMAM dendrimers bind to the major groove of the siRNA structure, while bPEI binds to both major and minor groove.
Maj.Sat.-mClover and Min.Sat.-mRuby were gifts from Maria-Elena Torres-Padilla (Addgene plasmid #47878 and #47880, respectively)7,51, which bind to the major and minor satellite DNA repeats directly.
These proteins were used as targets for affinity-based selection of scFvs that bind to the major outer membrane protein, OmpA; the polysaccharide capsule protein KpsF; a protein component of the type IV pilus (CapF); and, two flagellar proteins FlhA and FlgI.
Spectroscopic evidence showed that Na2SeO4 and Na2SeO3 bind to the major and minor grooves of RNA (via G, A and U bases) with some degree of the Se phosphate (PO2) interaction for both compounds with overall binding constants of K(Na2SeO4 RNA) = 8.34 × 103 and K(Na2SeO3 RNA) = 4.57 × 103 M−103
The expression of the 11S particle is induced by interferon gamma and is responsible, in conjunction with the immunoproteasome β subunits, for the generation of peptides that bind to the major histocompatibility complex.
Similar(47)
Tumour-specific antigens represent fragments of novel peptides (small proteins) that are presented at the cell surface bound to the major histocompatibility complex class I molecules.
Results from molecular docking and plasmid relaxation assay suggest that FCP5 binds to the major groove of DNA with a preference for adenosine thymine base pair sequences and directly induces DNA strand breaks.
(5) According to a recent study, if a protein binds to the major groove, it should associate with DNA in a sequence specific manner [38] [40].
In addition, intravenously- injected ICG shows no extravasation except in abnormally permeable vasculature because ICG binds to the major serum protein, albumin [14].
The majority of the C. rodentium infected mice developed systemic infection and colitis in the mid and distal colon by day 12. C. rodentium bound to the major secreted mucin, Muc2, in vitro, and high numbers of bacteria were found in secreted MUC2 in infected animals in vivo, indicating that mucins may limit bacterial access to the epithelial surface.
More suggestions(19)
bound to the major
linked to the major
relates to the major
bind to the principal
connects to the major
bind to the N-terminal
bind to the complex
bind to the mature
bind to the corresponding
bind to the α5β1-domain
bind to the Erb3-binding
bind to the incompatible
bind to the extracellular
bind to the activated
bind to the globular
bind to the immobilized
bind to the hydrophobic
bind to the same
bind to the extensive
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