IGF2BP2 binds to the key growth and insulin signaling molecule insulin-like growth factor 2 (IGFII) and is highly expressed in pancreatic islets [3].
The theory is 'clean': one makes an antibody against, say a purified protein and the antibody is supposed to bind to the antigen like a key fits a lock.
Visualization of how drug-like molecules bind to the target protein is a key step in driving follow-up or preclinical chemistry to improve characteristics of the molecule.
Furthermore, some anti-cancer agents like piperlongumine bind to the active sites of several key cellular antioxidants including glutathione S transferase and carbonyl reductase 1 only in the cancer cells.
By mimicking β-estradiol, TBBPA can bind to the human estrogen sulfotransferase (SULT1E1), a key hormone metabolizing enzyme, and it was also reported to induce transcription of E2-activated genes in mosquitofish in vivo.
Speech interfaces are bound to become the key to intelligent human-machine interaction and Indisys dialogue technology will make these interfaces more flexible, intelligent and human-like.
DOI: http://dx.doi.org/10.7554/eLife.02046.009 Wdirectlyctly binds to the chromatin of key genes required for in ESC self renewal (Ang et al., 2011).
Although no common motifs have been found to date, we also investigated the possibility that proteins previously reported to bind the key region of PreS shared motifs with the phage display peptides.
To confirm that ZFHX3 binds to the promoter of the key predicted target genes Avp and Vip in vivo, we performed quantitative ChIP on SCN tissue from Zfhx3 +/+ animals (ZT3) using ZFHX3 antiserum.
Neurexin has been shown to bind to several key synaptic proteins, including the synaptic vesicle protein synaptotagmin, the synaptic scaffolding proteins Mint and CASK, and the cell adhesion molecules neuroligin and LRRTM2 [25], [26], [27], [28], [28].
