It is generally accepted that MVI fulfills its functions through interactions with actin and a set of interaction partners bound to the MVI C-terminal globular tail domain (cargo domain) in the tissue- and/or cell type-specific manners.
It has been widely accepted that MVI fulfills its functions through interactions with actin and a set of its interaction partners bound to the MVI C-terminal globular tail domain (also termed the cargo domain) in tissue- and cell type-specific manners.
The C-terminal residues of τ500 (residues 622 643: not modeled) bind to the tail of the polymerase, while the globular domain of τ500 binds to the polymerase fingers domain (see Figure 2 figure supplement 2 for more details).
The nature of these assays favored the isolation of antibodies that bound predominantly to the globular head of the virus and inhibited binding of the virus to the host cells.
In essence, the C84 fullerene cage mimics the rigid globular structure of the μ-conotoxin molecule, and the lysine derivatives mimic the flexible positively charged arms of μ-conotoxin which are shown to bind to the channel and within the selectivity filter of NavAb [16].
Three non-SMC condensin subunits (Cnd2/Barren and HEAT repeat-containing Cnd1 and Cnd3) are bound to the ATPase-containing globular domains of the SMC heterodimer (Sutani et al. 1999; Yoshimura et al. 2002).
The RING subunit binds to the cullin's globular carboxy-terminal domain and acts as an E3 ubiquitin ligase responsible for recruiting the complex's ubiquitin conjugating enzyme (E2).
We have modeled ADIPOR1 receptor because it is known to bind the globular part of ADIPOQ (i.e. without the related collagen part).
Recently, the crystal structure of the C-terminal part of human Pex19 was solved, which revealed that mPTSs bind to a globular α-helical domain in the C terminus of the protein (Schueller et al. 2010).
The relative independence of the helical orientation provides a large interface for each helical motif to bind with the globular Ub molecule individually; and one AT3-UIM12 can potentially bind with two Ub molecules.
