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The results showed that all of these compounds bind to the binding site of BCRP with relatively suitable binding energies and therefore could be potential inhibitors of both αβ-tubulin and BCRP proteins.
These coordinates were chosen and calculated to aid the epitope sequence to bind to the binding groove of the receptor.
In contrast, DNA fragments immunoprecipitated by JMJD2A antibody yielded a 183-base product that spanned nucleotides (−524 to −341), suggesting that JMJD2A could directly or indirectly bind to the binding site of E2Fs.
It revealed that RUNX3 could directly bind to the binding site 3 (BS3) region but not the binding site 1 (BS1) and 2 (BS2) region in SGC-7901 cells treated with cisplatin or doxorubicin.
Validation of docking protocol and the size as well as center of the coordinates of the grid was carried out in order to ensure that ligands bind to the binding pocket in the correct conformation.
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There are crystallographic studies reporting stacking interactions between leucine residues when free leucine binds to the binding site of leucine/valine/isoleucine binding protein [53].
After absorption, vitamin D is bound to the binding protein and carried to the liver via the bloodstream.
Additionally, being part of the gene regulation process, the TF of a regulatory link binds to the binding site containing the TF binding site (TFBS) motif, which is generally located upstream of the TG sequence [ 22].
β-mannose on the lipoplexes shields the cationic characteristic of DOTAP and prevents nonspecific binding, whereas α-mannose not only exhibited the same effect as β-mannose but also was definitely recognized and bound to the binding site.
In previous studies, all peptides were assumed to bind to the SH3 binding pocket in the canonical binding mode.
Activated GTP-bound Rho proteins bind to the GTPase-binding domains and occlude DAD binding to DID, thus alleviating its inhibitory influence over the FH2 domain (Goode and Eck, 2007).
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