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PAHs have been shown to bind to the aryl hydrocarbon receptor and affect multiple systems (Nebert and Atlas 1978).
Dioxins bind to the aryl hydrocarbon receptor (AhR), which, after dissociating from its complex of chaperone proteins in the cytoplasm (including HSP90 and XAP2) translocates to the nucleus.
In rodents, PCBs bind to the aryl hydrocarbon (AhR) and pregnane X receptors (PXR) inducing the expression of catabolic cytochrome p450 enzymes of the CYP1A and 3A families.
PAHs and/or their metabolites may bind to the aryl hydrocarbon receptor (AhR) and accumulate in the nucleus of cells, resulting in increased rates of mutagenesis.
Based on their analyses, the researchers conclude that TCDD and other compounds that bind to the aryl hydrocarbon receptor do not affect sperm creation.
DLCs, including some PCB congeners, bind to the aryl hydrocarbon receptor (AhR) and activate the hepatic uridine diphosphate glucuronyltransferase (UDP-GT) enzymes responsible for T4 glucuronidation, resulting in T4 excretion in bile.
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Upon ligand binding, the AhR binds to the aryl hydrocarbon nuclear translocator (ARNT) protein, resulting in translocation to the nucleus, where the ligand AhR ARNT complex binds to response elements in the promoter of AhR-regulated genes (dioxin response element).
Subsequently, Kyn binds to the aryl hydrocarbon receptor (AhR), which translocates from the cytoplasm to the nucleus, where it can drive expression of various genes [73].
Sodium tetraphenylborate can also be classified as an organosodium compound since in the solid state sodium is bound to the aryl groups.
A dioxinlike compound is a compound that binds to the aryl hydrocarbon (Ah) receptor, results in dioxinlike effects, and bioaccumulates.
2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD) is a persistent environmental contaminant that binds to the aryl hydrocarbon receptor (AhR) which then translocates to the nucleus and dimerizes with the aryl hydrocarbon receptor translocator (ARNT) [ 26, 27].
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bind to the β-tubulin
bind to the surface
bind to the peptide
bind to the promoter
bind to the estrogen
bind to the tyrosinase
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bind to the active-site
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bind to the AhR
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bind to the lipophilic
bind to the interspace
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