Sentence examples for bind to the apc from inspiring English sources

The MCC might bind to the APC as a pseudosubstrate due to a KEN-box motif in BubR1 [53], [57], [58], [58].

In the "Convey variant", we do not assume that the APC MCC complex simply dissociates into APC and MCC, but that the MCC complex falls apart so that the Cdc20 contained in the MCC complex can bind to the APC (Eq. (7b)).

It was presented that exosomes first bind to the APC surface and then are internalized by DCs.

15 When bound to the APC, GM-CSF stimulates upregulation of other key immune function molecules, including cytokines and costimulatory molecules.

Another important factor is miR-135a, which binds to the APC gene [ 43, 44], and inhibits STAT3-induced pro survival gene expression and induces apoptosis in gastric cancer and lymphoma [ 45].

However, there are no known enzymes below activated β-catenin that could be inhibited, and the protein interaction surface between β-catenin and TCF is highly unsuitable for disruption by small molecule inhibitors since it is extensive, and because negative regulators of β-catenin such as Axin and APC bind to the same TCF-interacting surface of β-catenin [ 49].

Both MAD2 and MAD2B can bind to the anaphase promoting complex or cyclosome (APC/C), which is a downstream target of the mitotic spindle checkpoint.

We believe this was because of the inability of BubR1 to bind to the APC/C complex and Cdc20 in the absence of its degron domains.

Thus Mad2p and Mad3p bind to the APC/C each mitosis, even under optimal growth conditions, demonstrating that the fission yeast spindle checkpoint is active every cell cycle.

Fission yeast Mad2p and Mad3p bind to the APC/C in mitosis [ 15], and we employed cdc25 block and release to determine whether this interaction was perturbed in the absence of Mph1 kinase activity.

The cyclin B1-Cdk1 complex has previously been shown to bind to the APC/C through its partner Cks1 protein, and this improves the efficiency of its destruction (van Zon et al., 2010).