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Synthetic and natural androgenic steroids (such as methyl-testosterone and testosterone, respectively) bind to the androgen receptor (AR), inducing an activation of the receptor (AR agonism) leading to transcription of genes responsible for androgenic effects.
If the tumor continues to grow, physicians prescribe other drugs that bind to the androgen receptor in the prostate cell's cytoplasm so that the hormone cannot land on the receptor and turn it on.
Figure 3 Three examples of searches of MTLs on the MTLD Internet server: (A) ligands that bind to the androgen receptor were queried in the "Protein" option; (B) ligands with the ligand-ID of "SAL" were queried in the "Lig" option; (C) ligands with structural similarity to that of dihydrotestosterone were queried in the "Structural" option.
In addition, certain progestogens may bind to the androgen receptor.
Androgens bind to the androgen receptor (AR) in prostate cells and are essential survival factors for healthy prostate epithelium.
The androgens bind to the androgen receptor (AR) and are transported into the nucleus to initiate DNA transcription mechanisms.
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OPP has been found to have estrogenic or anti-androgenic activity, and binds to the androgen or estrogen receptors [ 7].
Testosterone is produced by the testicular Leydig cells (LC) and binds to the androgen receptor (AR) to modulate gene transcription in target cells [4].
Testosterone binds to the androgen receptor in target tissue to mediate its effects.
IFI16 also binds to the androgen receptor to up-regulate both its expression and activity (18).
The more potent 5 α-DHT binds to the androgen receptor (AR).
More suggestions(17)
bind to the promoter
bind to the end
bind to the tyrosinase
bind to the target
bind to the active-site
bind to the glucocorticoid
bind to the bone
bind to the dialysis
bind to the invading
bind to the host
bind to the cell
bind to the repeat
bind to the serotonin
bind to the AhR
bind to the protein
bind to the p450
bind to the block
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