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Ligand binding stabilizes the LBD in the active conformation; as such coactivator and RXR can bind to the activated LBD [ 24].
Therefore, at low concentrations, they bind to the activated receptors only.
Ly6Chigh monocytes preferentially bind to the activated endothelium in atherogenic ApoE knockout mice and infiltrate the developing atheroma to give rise to lesional macrophages and, eventually, foam cells [26,37].
It is very unlikely that BSA molecules could directly bind to the activated Si sites through a covalent bond because of, firstly, the highest probability which water molecules have to saturate with EBAPS dangling bonds.
This RING-SH2Drk chimera should be able to bind to the activated EGFR on pY1068 or pY1086 that can be recognized by the SH2 domain of Drk.
Although these molecules naturally evolved to efficiently bind to the activated platelet-specific integrin αIIbβ3, thus disrupting the process of platelet aggregation (the final step in blood clotting), most purified snake venom disintegrins are rather promiscuous in that they bind to several β1, β3 or β5 integrin members, albeit with different affinities and selectivity [25].
Similar(49)
Results: In vitro studies: All three carriers preferentially bound to the activated rather than to quiescent HSC.
Cell surface NKG2D ligands (NKG2DL) bind to the activating NKG2D receptor present on NK cells and subsets of T cells, thus playing a role in initiating an immune response.
In this scheme, ATP cannot bind to the immobile activated complex unless γ = 2 ADP molecules are already bound.
These primers had a C6 amine modification in the 5' end in order to bind to the glutaraldehyde activated aminosilane-coated slides.
The murine cytomegalovirus (MCMV) induces in infected cells expression of the virus-encoded GPI-anchored m157 protein, which binds to the activating, DAP12-associating killer receptor Ly49H in MCMV-resistant mice leading to NKcell-mediated cytotoxicity.
More suggestions(15)
bind to the anionic
bind to the active
bind to the intracellular
bind to the specific
bind to the cytosolic
bind to the complementary
bind to the mitochondrial
bind to the full
bind to the inactive
bind to the external
bind to the regulatory
bind to the proximal
bind to the canonical
bind to the primary
bind to the human
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