Sentence examples for bind to target proteins from inspiring English sources
The results showed that analogues could significantly bind to target proteins and exhibited anti-cancer effect against three cancer cell lines.
If three of these four residues are replaced, the mutant DSS1 almost becomes unable to bind to target proteins.
These libraries not only reduce waste by eliminating compounds that are unlikely to bind to target proteins, but often lead to the increased potency and specificity of binders, as demonstrated for c-Src kinase [13].
SUMO1 can bind to target proteins as part of a sumolation modification system.
Ubiquitin can bind to target proteins via an isopeptide bond via different Lys residues of the ubiquitin (polyubiquitin chains).
The core of this sequestration model is a nuclear export signal (NES -like domaiNES -likethe 14-3-3 molecules that bindomainarget proteins.
In total, the presented results suggest that the majority of CaM is bound to target proteins spatially differentiable at rest and following Ca2+ elevations, implying that CaM-dependent protein activation occurs through competition for a limited pool of available CaM.
The PLK1-PBD generally binds to target proteins after their phosphorylation on Ser/Thr- sites within a PBD-docking motif (Cheng et al., 2003; Elia et al., 2003a, 2003b; Yun et al., 2009; Xu et al., 2013); however, in the context of the Drosophila microtubule-associated protein Map205 phospho-independent binding has also been described (Archambault et al., 2008).
Previously, RNA isolated by native RIP was analyzed with microarray technologies (RIP-ChIP) [ 54], but this is naturally limited by array design and coverage, so nRIP has recently been coupled with high-throughput sequencing (nRIP-seq) to capture the genome-wide RNA pools bound to target proteins [ 55].
