SUMO1 can bind to target proteins as part of a sumolation modification system.
The activated, hormone bound GR translocates from the cytoplasm to the nucleus, and binds to target gene regulatory regions.
Fabs could bind to the target modification stably and block the access of cellular factors to the modification; however, Fab binding was transient and did not interfere with cell division.
We considered that aptamers could overcome this problem because aptamers bind directly to target proteins.
We assigned both the preferentially bound intervals and the qualitatively uniquely bound intervals to target genes.
It was expressed as the following ratio: aptamer pool bound to target-containing beads/aptamer pool bound to empty beads.
The conclusion was that MYC actually requires certain modifications to bind to the target E box and that binding is a signal for further modifications.
Binding of HamRz to target sequence depends on complementary match with homologous target site.
Other epigenetic players bind to epigenetic modifications ('readers') and recruit further re-enforcing complexes.
When miRNAs completely bind to their target mRNAs, degradation of the target mRNAs will be initiated.
