Sentence examples for bind to target genes from inspiring English sources

These ODNs acted as 'decoys', binding to cellular NRSF and inhibiting its ability to bind to target genes (McClelland et al., 2011a).

For animal miRNAs, target prediction is an issue because miRNAs can bind to target genes without perfect complementarity [ 7].

Mad competes with Myc bHLH TFs to dimerize with Max, and bind to target genes containing E-box sequences (5'-CANNTG-3') [ 11].

Although the transcriptional repressor Bcl-6 may directly bind to target genes, it exerts its effect on Blimp-1 indirectly through AP-1.

An LHP1-CD*-GFP fusion did not efficiently bind to target gene chromatin and had lost its correct sub-nuclear distribution, suggesting that chromodomain-mediated binding to H3K27me3 is essential for LHP1 targeting in vivo.

Upon binding their ligands, PPARs heterodimerize with the 9-cis-retinoic acid receptor and then bind to target gene peroxisome proliferator response elements, a direct repeat of the sequence AGGTCA separated by one nucleotide [ 3].

Under basal conditions, KEAP1 associates with NRF2 and targets it for degradation, and then modified KEAP1 by oxidative reagents will dissociate with NRF2 that could translocate into nucleus, bind to target gene ARE element, and promote many antioxidant enzyme gene expressions [ 62, 63].

Instead, Bcl-3 binds to target genes by binding directly to promoter-bound homodimers of nuclear factor NF-kappa-B p50 subunit (p50) or nuclear factor NF-kappa-B p52 subunit (p52) and subsequently induces either transactivation or repression of target gene [ 5].

As a matter of fact, we detected a considerably higher degree of p53 phosphorylated at S46 bound to target genes upon Etoposide treatment, although binding of p53-pS46 in in principle also present in cells treated with Actinomycin D. Analyzing the bound targets in more detail, we found that the DNA-binding of p53 phosphorylated at S46 is not restricted to apoptotic target genes.

Phosphorylated Smad2 acts as a transcription regulator and binds to target genes to induce transcription.

However, in the basal state, ELK4 is already bound to target genes poised for zymosan induction.