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The specific localization is mediated by RNA binding proteins, such as Staufen and Exuperantia, which bind to specific regions of the 3'-UTR of both Nanos and Bicoid and, via interactions with cytoskeleton-anchoring proteins and motor proteins, are translocated to their respective destination locations [ 11].
Activators bind to specific regions of the DNA in the upstream regulatory region, some very distant from the binding of the initiation complex.
For example, proteins that bind to specific regions of DNA act as transcription factors by activating or repressing gene expression of the DNA.
The paradigm for genome engineering shifted seemingly overnight in late 2009 with the discovery that TALEs proteins produced by Xanthamonas bacteria to regulate transcription in their host plant cells could bind to specific regions of DNA.
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Rather than binding directly to specific DNA sequences in the hly operon, Hha exhibits nonspecific DNA binding; therefore, it was proposed Hha binds to H-NS, which binds to specific regions of regulatory sequences in the hly operon [17].
These data suggest how the HCV IRES binds to specific regions of eIF3 to target the translational machinery to the viral genomic RNA and provide a framework for modeling the architecture of intact human eIF3.
Our results appear to corroborate a previous report indicating that α-crystallin binds to specific regions of DNA in mouse γD/E crystallin genes [45].
When Fur is bound to its iron (Fe2+) co-factor, it binds to specific regions in iron-regulated promoters called Fur Boxes and blocks the binding of RNA polymerase.
Here, we revealed that p53 binds to specific regions into the promoters of the genes relative to MVA pathway independently from SREBP1 and SREBP2 proteins.
This complex binds to specific regions of DNA and is thought to allow stem cells to remain able to become different cell types by repressing the genes required for adopting a specialized cell fate.
In one of the loops (core loop), the two transcription factors BMAL1 and CLOCK form a complex that binds to specific regions of DNA called enhancer-boxes (E-boxes).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com