These proteins bind to specific sites on DNA and (for example) turn on expression of specific genes.
The mechanisms that target Kinesin to specific cargos outside of the neuron are less well understood.
This Arg residue is located in a positively charged region of AP2σ2 that binds to specific peptide motifs on membrane cargo proteins (18).
Sorting signals are required to target specific cargoes to the right destinations, although the signals and machinery needed for cargo sorting are not entirely understood.
All importin β members have the ability to recognize and bind specific cargo involved in the recognition of the host and signaling [ 29, 30].
Kinesins bind to various cargoes via several different adaptor proteins [28].
Sec24 and its isoforms each have multiple cargo recognition sites that bind to membrane cargoes.
As mentioned above, during an import cycle, Kaps bind to their cargoes in the cytoplasm, and when they reach the high Ran-GTP in the nucleus, are induced to release their cargoes.
TRAKs bind to the cargo binding domain of conventional kinesin-1 heavy chains forming a link between the motor protein and cargo [2 4].
Molecular motor proteins bind to the cargo and to the filaments and move the cargo along the fiber, always in a specific direction depending on the type of motor and fiber.
