Sentence examples for bind to small target from inspiring English sources
The latter can covalently bind to small target proteins and acquire a greater apparent molecular mass.
Argonaute (AGO) proteins bind to small-interfering (si RNAs and micro (mi RNAs to target RNA silencing against viruses, transgenes and in regulation of mRNAs.
Three of the cis-sRNAs were predicted riboswitches that could directly bind a small target molecule.
ATP mimetics are orally administered small molecule agents that bind to the target kinase ATP-binding pocket and compete with ATP for binding (Table 1).> -wrap-foot> BCR-ABL break point cluster region-Abelson, bid.
Aptamers are short stretches of nucleotides or amino-acid residues that are engineered to bind to various targets, from small chemicals to large proteins and live cells.
The interactions between small molecules and proteins are important for receptors, transporters, or enzymes to recognize their substrates as well as for small molecule therapeutics to bind to their target protein.
MicroRNAs (miRs) are small non-coding RNAs that bind to the target transcript in the 3′-UTR and can inhibit the translation of proteins and destabilise their target mRNA (Baek et al, 2008).
The expression of BDNF is influenced by many factors, and epigenetic regulation plays an important role in BDNF expression changes induced by environment contaminants and in neurodegenerative diseases [ 48]. miRNAs are endogenous, small RNAs that bind to target mRNAs and regulate gene expression by repressing translation of target mRNAs.
Consequently, binder molecule development depends to a large extent on the small molecule binders that are available and known to bind to the target.
Virtual screening of small-molecule collections has become a widespread practice both in academic laboratories and in pharmaceutical companies to rapidly and inexpensively identify small molecules which bind to the intended target with sufficient affinity to facilitate initiation of a drug discovery project.
