Sentence examples for bind to small GTPases from inspiring English sources

Furthermore, some BAR domains have been found to bind to small GTPases, a class of intracellular molecular switches (Tarricone et al, 2001; Habermann, 2004); thus, their membrane association is directly linked to regulation of signal transduction and trafficking.

In contrast to small GTPases, relatively little is known about the mechanisms mediating the localization of GTPases from the family of guanylate-binding proteins (GBPs).

Arfaptin-1 was reported to bind to curved membrane structures with its crescent shaped Bin/Amphiphysin/Rvs (BAR) domain., In addition to curved membranes, Arfaptin-1 also binds to activated small GTPases of the ARF family.

Related repeats to the LRRs are known to bind small GTPases of the Ras superfamily (Jou and Nelson, 1998; Kaibuchi et al, 1999).

The Mog1 protein binds to the small GTPase Ran that plays an important role in nuclear import.

β-karyopherins were originally identified based on their ability to bind the small GTPase Ran through an N-terminal binding domain [ 9].

A structural study on the closely related protein Arfaptin-2 has revealed that Arfaptins can cooperatively bind small GTPases of the ARF family and curved membranes.

GAPs are a family of regulatory proteins whose members can bind and activate small GTPases and others G proteins.

For example, PH domains in some guanine nucleotide-exchange factors (GEF) have been shown to bind directly to their cognate small GTPases (Rossman et al, 2002, 2003; Lu et al, 2004), and our data now show direct interaction between the APPL1 PH domain and Rab5.

Rev binds to the nuclear export protein Crm1 which in turn binds to Ran, a small GTPase that shuttles between the nucleus and the cytoplasm.

Their phospholipid composition changes (i.e., acquire phosphatidylinositol 3-phosphate) and they bind the small GTPase Rab5 and early endosomal antigen 1 (EEare, are tethered to microtubules and become classical early endosomes.