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RGD-binding integrins bind to several ligands (both extracellular matrix and soluble), suggesting mechanisms to explain the influence of integrins on diverse cellular processes.
Moreover, peptides selected for binding to certain receptors bind to several sites on the receptor and activation might occur through conformational changes rather than multimerization [54].
Although antibodies were found to bind to several HIV proteins, these HIV-binding antibodies do not lead to an effective immune response.
Such a combined model could then cater for proteins that bind to several ligand types (with non-identical binding sites per ligand) and that are regulated by multiple allosteric activators or inhibitors.
Here we show the carbohydrate-binding domain is crucial for its stability and ability to bind to several glycogen-associated proteins.
Gcn4p is a basic leucine zipper protein which interacts with DNA binding sites as a dimer [ 32], and is known to preferentially bind to several sequence motifs, including a 7-mer motif, TGACTCA [ 33, 34].
A mi-RNA can bind to several smRNA.
It can be clearly seen that nearly all inhibitors bind to several kinase groups.
A ligand is a small molecule bind to several residues of a receptor.
After intravenous administration, heparin can bind to several molecules and platelets that can result in reduced biologic availability.
A prerequisite for drug repurposing is drug promiscuity (polypharmacology), which is a drug's ability to bind to several different targets.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com