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For long it has been known that mothers with anti-Ro antibodies have increased risk for fetal heart block (congenital heart block, CHB) and mothers of babies with CHB have anti-HERV3 antibodies that bind to sections of fetal heart [77].
One way of doing this is to activate or inactivate proteins called transcription factors, which bind to sections of DNA to alter the expression of nearby genes.
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To study how the tau protein goes awry, Marie Luise Schmidt, working in the lab of University of Pennsylvania School of Medicine neurobiologists John Trojanowski and Virginia Lee, created a set of antibodies designed to bind to different sections of tau molecules.
The researchers designed a way to block the expression of this gene using antisense oligonucleotides – short sequences of DNA that bind to a section of the gene of interest, thereby preventing gene expression.
The experiments show that both of the sensor proteins can bind to a section of the BiP chaperone called the ATPase domain.
To activate a gene, proteins called transcription factors bind to a section of DNA within the gene called the promoter.
Our protein protein interaction experiments found that the SEP domain of UBXN2A binds to a section of p53's binding site on mot-2, which contains three binding amino acids used by p53: PRO442, LYS555, and ILE558.
The experiments show that the loop specifically binds to a section of substrate proteins called the transmembrane segment that spans the cell membrane.
Once the top flange is removed, BP has to bind together two sections of drill pipe that are in the gushing well head.
Descostes, Heidemann et al. also found that RNA Polymerase II with phosphate tags on tyrosine-1 also binds to, and transcribes, sections of DNA called 'enhancers', which are outside of the genes but that help to activate nearby genes.
Some bind to stretches of DNA.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com