Sentence examples for bind to regulatory sequences from inspiring English sources

The processed miRNAs most frequently bind to regulatory sequences in the 3'- untranslated region (UTR) of target mRNAs through imperfect base-pairing, resulting in translational inhibition or degradation of protein-coding transcripts [2].

IRP's bind to regulatory sequences in the Tfrc mRNA 3' untranslated region and stabilize the messenger RNA promoting production of transferrin receptor protein [42], [43], [44] thereby increasing iron delivery.

This raises the possibility that critical DNA demethylation may facilitate transcription factor(s) downstream of CSF2 to bind to regulatory sequences of CD24 and MMP-2, with a consequential increase in Wnt/β-catenin signaling, which has been previously reported in pterygium [41].

Key to this control is the recruitment of transcription factors (TFs) that bind to regulatory sequences, such as promoters, enhancers, repressors and insulators.

Rather, our results suggest the presence of a regulatory protein in Mishca protoplasts that responds to UV-B, which may be able to bind to regulatory sequences in the promoter of P1.

This trimeric Smad complex binds to regulatory sequences in the E cadherin promoter, leading its repression and subsequent loss of adherens junctions [ 12].

ChIP-seq data from multiple studies in different cell line backgrounds reveal that BRG1, as expected, binds to regulatory sequences at target genes but also binds elsewhere throughout the genome, with a significant proportion of the total binding sites being intergenic.

In Smad-dependent signalling, Smads and Snail (EMT transcription factor) bind to regulatory promoter sequences of the gene encoding E-cadherin, leading to TGF- β-induced suppression of its expression (Vincent et al, 2009).

Finally, we found Desmoplakin to be a direct transcriptional target of Bcl11b in dentate granule cells, and demonstrate that Bcl11b binds directly to regulatory sequences in close proximity to the transcription start site of Dsp, which includes putative Bcl11b binding sites (Avram et al, 2002; Cismasiu et al, 2006).

Thus, despite differences at the protein sequence level, HSF4 and HSF1 are strongly conserved at the DNA-binding domain level and are therefore likely to bind to similar regulatory sequences on the DNA [9].

The homeodomain, with its helix-turn-helix structure, binds to regulatory DNA sequences of target genes, while the LIM domains are mainly involved in protein-protein interactions that regulate the activity of the LIM-HD [ 22].