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E2F proteins, which share a conserved DNA binding domain, can bind to overlapping sets of target promoters.
The only threat to self-limiting growth in this scenario is the possibility that two glue particles bind to overlapping sets of shell monomers.
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First, the activator Vac7p and the inhibitor Atg18p bind to overlapping sites, close to the site of Fab1p.
GSH and GS-X bind to overlapping sites on Kef, which are located in a cytosolic regulatory domain.
In conclusion, SCL and these repressors bind to overlapping and distinct functional categories of activated and repressed target genes.
Yet, they bind highly overlapping sets of 8-mers and produce motifs featuring CTACA.
In general, responsiveness within the same family of ligands is highly correlated, likely because such ligands can bind overlapping sets of receptors.
These cases do not always correspond to TFs that have related DNA sequence specificity; for example, Rap1 and Fhl1, which coregulate ribosomal protein genes, bind overlapping sets of promoters despite having very different sequence specificities.
ChIP-chip data reveal that the genes encoding the subunits of Ribosome 60S, RNA polymerase and eIF2B are bound by overlapping sets transcription factors.
Hox proteins bind specific DNA sequences via the homeodomain, and are thought to regulate overlapping sets of target genes, although the molecular pathways controlled by Hox proteins are only starting to be unveiled [ 9].
As the likes of Apple, Nokia and, perhaps, Google move to give mobile users "the complete experience," they are bound to overlap more and more not just with each other, but with others in the mobile business.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com