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Constitutive overexpression of TFs can produce neomorphic phenotypes that do not necessarily reflect genuine functions of the TFs investigated [ 51], because overexpressed TFs occasionally bind to nonphysiological targets.
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New approach generates a wider variety of protein sequences optimized to bind to drug targets.
(E) Statistical analyses of the target number of ligands included in the MTLD: 795 ligand entries bind two targets; 551 ligand entries bind 3 5 targets; 189 ligand entries bind 6 10 targets; and 197 ligand entries bind to >10 targets; (F) Comparison of the conformation of a ligand bound to different targets.
This (indirect) diversity measure has its disadvantages as similar ligands can bind to different targets or alternatively, structurally diverse ligands may bind to the same target.
CaM and CaM-like proteins bind to their targets by anchoring hydrophobic residue of the target.
Drugs that bind to common targets likely exert similar activities.
Secondly, they anchor various molecules to the sides of the nanowire that bind to specific biological targets.
Finally, PPI targets usually lack natural molecules that bind to the target PPI interface.
Each probe is designed to bind to a target DNA.
MiRNAs bind to their target genes based on sequence complementarity.
When miRNAs completely bind to their target mRNAs, degradation of the target mRNAs will be initiated.
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