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In order for a drug to bind to multiple targets, the interaction sites of these targets must be similar on a molecular level.
Among the panoply of privileged structures, our research group has focused its attention on the chromone (4H-benzopyran-4-one) scaffold due to its chemical versatility and ability to bind to multiple targets.
A current key feature in drug-target network is that drugs often bind to multiple targets, known as polypharmacology or drug promiscuity.
Some drugs have the ability to bind to multiple targets in one cell; for example, they could bind to both cell membrane (M) and soluble (S) targets.
The fact that the N- and C-terminal regions of Cby are somewhat independent may be crucial for the protein to bind to multiple targets via the distinct structural modules located in these two segments.
More recently, multispecific designs have been generated in which a single protein interface sequence is simultaneously optimized to bind to multiple targets, producing a so-called "hub" protein (79).
Similar(48)
In line with this, we find that RBM47 binds to multiple target mRNAs.
5, 6 Single miRNA binds to multiple target mRNA, and regulates various cellular functions including proliferation, differentiation and metastasis.
The background of this statement lies in the fact that most drugs are able to bind to multiple protein targets in the human body, this is known as polypharmacology.
However, it should be kept in mind that the compounds used may bind to multiple cellular targets.
The most dangerous kinds of man-made toxic chemical agents, those that kill cells or organisms, exhibit a rich diversity of chemical structures and can bind to multiple cellular targets, to the extent that a unitary mode of action is not considered likely.
More suggestions(15)
bind to exogenous targets
bind to similar targets
bind to multiple receptors
bind to distinct targets
bind to specific targets
bind to multiple loci
bind to multiple isomers
bind to irrelevant targets
bind to multiple types
bind to multiple partners
bind to multiple 3'UTRs
bind to multiple ligands
bind to common targets
bind to unknown targets
bind to multiple elements
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