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Exact(12)
The ability of a protein to bind to multiple partners was suggested to involve new principles [ 26].
What if a region used to bind to multiple partners uses different secondary structures and different amino acids?
That is, it uses the same or similar face of its globular structure to bind to multiple partners.
Chameleon behavior could be an important feature that enables one disordered region to bind to multiple partners.
In the case of p53, different regions in the disordered tails enable this protein to bind to multiple partners at the same time.
These data support the conjecture that hub proteins often utilize intrinsic disorder to bind to multiple partners and provide detailed information about induced fit in structured regions.
Similar(48)
Many proteins function by binding to multiple partners.
These bioinformatics studies include further refinement of the analysis with the suggestion that disorder is very commonly used for regions that bind sequentially to multiple partners (so called "date hubs" [ 134]).
Proteins associated with human diseases, such as cancer, are enriched in intrinsic disorder: they enter in high-specificity-low-affinity interactions and one-to-many binding mode by which a single IDP/IDR binds to multiple structurally diverse partners, accomplished by their plasticity [ 21].
Proteins that interact primarily through one tight binding site allow the clamp to bind multiple partners at once, so that, as suggested in earlier studies, the clamp can be a sliding tool belt on DNA [ 78- 80].
Similarly, small backbone shifts and side chain conformational changes are both important for 14-3-3 14-3-3 14-3-3bind multiple partners.
More suggestions(18)
bind to numerous partners
bind to many partners
bind to multiple ligands
bind to multiple loci
bind to multiple sites
bind to multiple promoters
bind to migratory partners
bind to multiple targets
bind to multiple CDKs
bind to multiple positions
bind to multiple isomers
bind to multiple FGFRs
bind to multiple synbodies
bind to multiple peptides
bind to multiple 3'UTRs
bind to multiple elements
bind to multiple PPREs
bind to disordered partners
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