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Hence, the molecular modeling studies predicted that the inhibitors can bind to multiple intermediates of the enzymatic reaction, as expected from non-competitive inhibitors.
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Most Wnt proteins can bind to multiple Frizzleds and vice versa, suggesting redundancy in vivo.
Neurotrophin proteins bind to multiple receptors (p75, TrkA-C) to modulate survival, functional and degenerative intracellular signaling and synaptic function.
Thus, saccharides with multi-cis-diols will bind to multiple PBA molecules.
Of these sequences, 62 contained nonamers predicted to bind to multiple HLA supertypes.
As targeting only requires partial complementarity, a single miRNA can bind multiple mRNA transcripts and each mRNA can be bound to multiple miRNAs.
Notably, inhibitors 1 and 3 do not bind to non-persulfurated 3MST, but bind to an intermediate persulfurated 3MST as determined by ITC and X-ray crystallographic analysis.
p150(Glued), a subunit of dynactin that has been shown to bind to dynein intermediate chain, underwent similar changes in its phosphorylation.
Thus, Gli2 binds directly to multiple sites located up- and downstream of the Ascl1 gene.
Now, you know that if the same group is in attendance at multiple weddings you're bound to need multiple dresses.
As assembly progresses, early binding proteins are incorporated into intermediates before late binding proteins, thereby spending more time bound to intermediates than the late binders.
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