Sentence examples for bind to multiple epitopes from inspiring English sources

We conclude that AZD9773 is clearly demonstrated to bind to multiple epitopes on TNFα and suggest that the polyclonal nature may account, at least in part, for the very high potency observed in cell-based assays.

The SELEX technique was also applied to the viral reverse transcriptase, which is essential for replication, and thereby RNA and DNA aptamers were identified that bound to multiple epitopes of the viral reverse transcriptase with high affinity and specificity [ 37, 38, 55].

Since essentially all HLA class II molecules tested were shown to bind to multiple promiscuous HIV-1 epitopes [32], it is expected that most individuals could develop broad T cell responses.

In an epitope-based vaccine, one way to ensure maximum coverage is to include multiple epitopes where each one could bind to multiple HLA molecules.

For example, peptide epitopes from pathogen antigens that bind to multiple MHC allotypes present in a population are needed for developing vaccines with broad protective immunity.

Our group has recently identified conserved CD4 epitopes from HIV that were able to bind to multiple HLA-DR molecules.

AZD9773 is clearly shown to bind to multiple sites on hTNFα by virtue of the size of the complex in solution, as well as the presence of multiple epitopes as revealed by a combination of different approaches.

The large polymorphism in MHC class I alleles makes it likely that a single epitope precursor binds to multiple MHC alleles [ 44].

The epitope vsyfkcvqkevlpsm (position 42 56) binds to multiple HLA-DR.B1 subtypes with scores ranging from 25 tout oft of 35 maximum score.

They bind to three distinct epitopes: epitope I (1a2y and 1jhl), epitope II (1p2c and 2iff) and epitope III (1j1x) (see Supplementary Section 5).

As a test case we have picked lysozyme and the five distinct antibodies that bind to three different epitopes: epitope I (1a2y and 1jhl), epitope II (2iff and 1p2c) and epitope III with 1j1x (see Supplementary Section 5).