Sentence examples for bind to multiple CDKs from inspiring English sources

Aside from the various GTPases, we also made an interesting discovery that SGTP can bind to multiple CDKs.

Furthermore, we demonstrated for the first time that SGTP binds to multiple CDKs, which may perturb the CDK-mediated phosphorylation and cell cycle progression.

CDKs activity can be regulated by cell cycle inhibitory proteins (CKI) that bind to CDKs or CDK-cyclin complexes.

Another level of cell cycle regulation is affected by the cdk inhibitors, which bind to cdk or cdk-cyclin complexes and inhibit their kinase activity.

p21cip1 can bind to various CDKs, including cyclin D/CDK4, cyclin E, and cyclin A/CDK2, and inhibits their kinase activity.

The cki family of proteins was originally identified by their ability to bind to G1 cdks, ultimately inhibiting kinase activity and preventing progression through the G1-S transition.

Essentially, at each cell cycle phase, specific cyclins bind to their respective CDKs to form cyclin-CDK complexes that promote phase-specific events 12, 13 (Fig. 2).

Association with Kip-family members depends on the ability of the cyclin to bind to cdks, whereas association with nuclear hormone receptors is prevented by cdk binding (Zwijsen et al, 1997).

Despite their distinct CDK-binding preferences, both Speedy/Ringo A and B can promote the maturation of Xenopus oocytes and all three Speedy/Ringo proteins can bind to and activate CDKs in vivo.

A number of phosphatases and kinases bind to CDKs as do the CDKIs.

The p27 could also bind to CDKs and act as CDKI as p21.