The recent demonstration that variant PRC1 complexes bind to many target sites, albeit at lower levels, independently of H3K27me3 suggests that PRC1 function may be more complex than previously envisaged (Tavares et al., 2012).
Consistent with this observation, we have shown previously that Tup1 remains bound to many targets even when transcriptional repression is relieved [17].
Inactivation of marR can lead to increased expression of marA, which binds to many target genes and reduces antibiotic accumulation [ 19].
Many other RNAs, including microRNAs, do not code for proteins, but instead bind to many messenger RNA targets, and repress their ability to be decoded into proteins.
"Dirty" drugs may bind to many different molecular targets or receptors in the body and so tend to have a wide range of effects and possibly negative side effects.
We find that the transcription factors Asense, Deadpan, Snail and Prospero bind to many of the same target genes.
However, there are miRNAs that bind to many mRNAs, and one mRNA can be the target of many miRNAs.
The inherent flexibility of the RGG box (Ramos et al. 2003) can also enable binding to several RNA targets, as has been shown for FMRP (Darnell et al. 2004) which binds to many RNA targets but an affinity for RNA that forms a stable G-quartet structure (Menon and Mihailescu, 2007; Ramos et al. 2003).
14-3-3 proteins can bind to many proteins; in case of budding yeast, 4%% of proteins in the cell are potential target of 14-3-3 14-3-3 14-3-3 these proteinsl and involved in various aspecthese many cellular activities (van Heusden 2009).
Deadpan and Snail bind to many neuroblast genes.
