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Moreover, a recent study showed that CREBH could bind to its unique response element (CREBHRE) in the target gene promoter to modulate transcription [ 10, 12].
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Unlike most amino acids, which are aminoacylated onto their cognate tRNAs, Sec is synthesized from serine in a multi-step reaction while bound to its unique tRNA[Ser]Sec [3].
RANKL binds to its unique receptor activator of NF-κB (RANK) [ 60], and the RANKL/ RANK pathway seems of crucial importance in osteoclastogenesis and the bone erosion process.
Thus, the evolutionary time scales of ERV insertions and the appearance of the zinc-finger gene that binds to its unique sequences should occur at the same time.
Binding of IL-17 to its unique receptor results in activation of the adapter molecule TNF-receptor-associated factor 6 (TRAF6), which is required for IL-17 signaling [ 12].
Only antibodies that will bind to a unique epitope will react specifically to its intended target protein.
The Saccharomyces cerevisiae coronin, ScCoro (CRN1), is known to bind to microtubules via its unique region between the β-barrel domain and the coiled-coil oligomerisation region.
Peptide or small molecule ligands that bind to a unique region of a protein can be used for orienting the protein and modulating its activity through specific ligand-protein interactions on a solid support [11] [13].
In principle, an aptamer can specifically recognize and bind to a unique ligand, leading to a structural change of an aptamer.
All amide moieties of the bengamide derivatives bind to the unique shallow cavity and interact with a flat surface created by His-212 of MtMetAP1c in the Mn II) form.
In addition, these two factors each bind to a unique set of targets as well.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com