Sentence examples for bind to its response from inspiring English sources
p53 can bind to its response element present in miR-145 promoter and can up regulate miR-145 expression.
NFκB activation relies on stimulus-induced IκBα phosphorylation and proteasomal degradation, allowing free NFκB to translocate into the nucleus and to bind to its response element on the DNA [ 13].
After ligand binding, VDR heterodimerizes with RXR and binds to its response elements (vitamin D response elements, VDREs) within its target gene promoters.
In the nucleus, CAR only binds to its response elements after forming heterodimers with the retinoid X receptor (RXR).
In active repression, NR2F2 binds to its response element, while in trans-repression NR2F2 inhibits transcription in the absence of its cognate binding motif or independent of nucleic acid binding [40].
In order to examine whether the NF- ��B pathway mediated the decrease in P-gp expression, we used a NF- κB response element luciferase gene reporter assay, in which luciferase activity increases as NF- κB binds to its response element.
NFATc1 binds to its response elements containing a consensus sequence of GGAAA, and its target genes in osteoclasts include cathepsin K, CLC-7 chloride channel, vacuolar proton pump subunit Atp6v0d2, etc (Kuroda and Matsuo, 2012).
After activation, the AR ligand complex migrates into the nucleus and binds to its response element, which together with coactivators initiates transcription and cellular responses (Brinkmann et al. 1999; Veldscholte et al. 1992).
Moreover, a recent study showed that CREBH could bind to its unique response element (CREBHRE) in the target gene promoter to modulate transcription [ 10, 12].
Thus, OCT4 specifically binds to its putative response elements in the miR-125b-1 miR-125b-1 miR-125b-1trong evidence that miR-125b-1 can be directly regulated by OCT4.
